Detalhe da pesquisa
1.
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.
Mol Psychiatry
; 25(11): 2786-2799, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30116027
2.
OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Proc Natl Acad Sci U S A
; 114(22): 5719-5724, 2017 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28507136
3.
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate.
Bioorg Med Chem Lett
; 29(14): 1714-1718, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31113706
4.
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.
Bioorg Med Chem Lett
; 29(16): 2224-2228, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31248774
5.
Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self-administration in rats.
Addict Biol
; 23(5): 1106-1116, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29044937
6.
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
Bioorg Med Chem Lett
; 27(2): 171-175, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939174
7.
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.
Bioorg Med Chem Lett
; 27(11): 2296-2301, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28442253
8.
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
J Pharmacol Exp Ther
; 356(1): 123-36, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503377
9.
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 26(13): 3029-3033, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185330
10.
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
J Neurosci
; 32(25): 8532-44, 2012 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22723693
11.
Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration.
Neuropharmacology
; 227: 109424, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36720403
12.
The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders.
Adv Neurobiol
; 30: 37-99, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36928846
13.
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
J Pharmacol Exp Ther
; 340(2): 404-21, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22088953
14.
Muscarinic receptor pharmacology and circuitry for the modulation of cognition.
Handb Exp Pharmacol
; (208): 121-66, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22222698
15.
Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
J Med Chem
; 65(8): 6273-6286, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35417155
16.
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome.
Neurobiol Dis
; 39(3): 283-91, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20423730
17.
Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates.
Neuropsychopharmacology
; 45(13): 2219-2228, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32868847
18.
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
J Neurosci
; 28(41): 10422-33, 2008 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842902
19.
Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.
Eur J Neurosci
; 30(2): 207-16, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19659923
20.
Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.
ACS Chem Neurosci
; 10(3): 1294-1299, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30474955